The standard disclaimer goes here. These statements haven't been evaluated by the FDA. These have just been our observations. There are a number of potential health benefits, some of which are listed below.
Cannabidiol May Protect The Nervous System and Help With Neurodegenerative Diseases
CBD was found to prevent toxic effects of neurotransmitter glutamate and radical oxygen species (ROS) in the brain, thus preventing brain cell death. (1, 2)
CBD has antioxidant activity greater than vitamin C (ascorbic acid) or vitamin E (α-tocopherol)
CBD may also protect brain cells from beta-amyloid toxicity, making it a potential therapeutic agent in Alzheimer’s and Parkinson’s disease
CBD may also protect the brain from ischemia. (5,6)
Early human studies showed a dose-related improvement in patients with Parkinson’s disease treated with 100–600 mg/day of CBD over a 6-week period (7)
However, another study failed to show any beneficial effect of a mixture of THC and CBD either on Parkinson’s disease or dyskinesia (8)
CBD has been shown to reverse cognitive deficits of Alzheimer’s disease in animal models (9)
CBD, due to its anti-inflammatory and antioxidant properties, may be a promising agent to treat and prolong survival in Amyotrophic Lateral Sclerosis (ALS) patients. (10)
CBD increased tumor cell death in leukemia and colon cancer.
Cannabidiol May Relieve Multiple Sclerosis Symptoms
Cannabis derivatives may relieve symptoms in multiple sclerosis patients. (11)
Sativex, a combination of CBD and THC, is effective and well tolerated in the treatment of muscle tightness, pain, sleep disturbances, and urinary incontinence in people with multiple sclerosis. (12, 13, 14)
Cannabidiol Fights Against Cancer
CBD and other chemicals found in Cannabis have an anti-tumor effect and could be used to improve standard cancer treatments. (15)
CBD successfully stopped cancer cells in multiple different cervical cancer varieties and decreased the ability of the cancer cells to produce energy, leading to their death. (16)
CBD treatment helps lymphokine-activated killer (LAK) cells kill cancer cells better. (17)
CBD increased tumor cell death in leukemia and colon cancer. (18, 19, 20)
CBD also decreased human glioma cell growth and invasion, thus suggesting a possible role of CBD as an anti-tumor agent. (21, 22)
Cannabinoids may be promising tools in combination therapy for breast and prostate cancer, due to their direct anti-tumor effects, their ability to improve the efficacy of conventional anti-tumor drugs, and their usefulness as palliative treatment. (23, 24, 25)
Cannabidiol Reduces Inflammation and Improves Autoimmunity
CBD reduces the growth of neutrophils, and their migration to a target. (26)
CBD also reduced the production of chemokines such as macrophage inflammatory protein-1 alpha (MIP-1 alpha) and macrophage inflammatory protein-1 beta (MIP-1 beta) by B-cells. (26)
Macrophages from animals treated with CBD produced higher levels of interleukin-12 (IL-12) and lower levels of IL-10.
Due to its anti-inflammatory role, CBD is a very promising therapeutic agent for a variety of inflammatory and pain-associated disorders.
Cannabidiol Has Therapeutic Potential for Schizophrenia
CBD is a potential treatment for psychosis. (27, 28)
CBD improves the symptoms of schizophrenia. However, what regions of the brain are affected and the mechanism of action producing this dynamic are currently not known. (29, 30)
Studies suggest that CBD has a pharmacological effect similar to that of atypical anti-psychotic drugs, but with fewer side effects. (31)
Cannabidiol May Help With Epileptic Seizures
CBD may be a promising therapy for treatment-resistant epilepsy. (32, 33)
In a survey including parents of children with treatment-resistant epilepsy, 84% of parents reported a reduction in their child’s seizure frequency while taking CBD. (34)
These children also experienced increased alertness, better mood and improved sleep; drowsiness and fatigue occurred as side effects.
After 3 months of treatment with a purified 98% oil-based CBD extract, 39% of children with treatment-resistant epilepsy had a more than a 50% reduction in seizures
Out of 8 patients, suffering from secondary generalized epilepsy resistant to anti-epileptic drugs, 7 had improvement of their disease state after receiving 200-300 mg/d of cannabidiol for as long as 4.5 months. (35)
Cannabidiol Relieves Pain. Even Chronic.
Studies suggest that cannabinoids may be a new class of drugs for the treatment of chronic pain. (36,37)
CBD significantly decreased chronic inflammatory and neuropathic pain in rodents. (38)
Cannabidiol, especially in a combination with THC, shows promising results for the treatment of postoperative pain, chronic pain associated with multiple sclerosis, cancer, rheumatoid arthritis and neuropathic pain. (39,40,41)
Sativex, a combination of CBD and THC as a sublingual spray, is effective in treating neuropathic pain in patients with multiple sclerosis and in cancer patients with advanced pain. (42,43)
A recent study has shown that CBD and opioids act together to relieve pain. (44)
50% reduction in seizures in 39% of children with treatment-resistant epilepsy after only 3 months. #cbd #changinglives
Cannabidiol Reduces Anxiety
Cannabidiol reduces anxiety in both healthy individuals and patients with social anxiety disorder. (45,46)
Studies showed that CBD significantly reduced anxiety and discomfort caused by public speaking. (47,48)
CBD also reduced anxiety caused by the use of THC. (49)
Researchers suggest that it may be effective for panic disorder, obsessive compulsive disorder and post-traumatic stress disorder. (50)
CBD is a potential therapy for posttraumatic stress disorder (PTSD) treatment.
Administered as needed, it appears safe, well-tolerated, and may be beneficial to treat a number of anxiety-related disorders like OCD, PTSD, GAD, depression, panic disorder
Cannabidiol Lowers Incidence of Diabetes
The study which included 4,657 adult men and women showed that current marijuana use was associated with 16% lower fasting insulin levels, and smaller waist circumferences, a factor connected to the onset of diabetes. (52)
Cannabidiol significantly reduces the development of diabetes in young non-obese mice, from 86% in non-treated mice to only 30% in mice treated with CBD. (53,54)
Cannabidiol can inhibit and delay the destruction of insulin-producing pancreatic cells and the production of inflammatory cytokines in diabetics. (54)
This data strengthen assumptions that CBD, which is known to be safe in man, can possibly be used as a therapeutic agent for treatment of type 1 diabetes at an early stage of the disease.
Cannabidiol May Be Beneficial In The Treatment of Rheumatoid Arthritis
Due to its anti-inflammatory effect, cannabinoids may provide relief of joint pain and swelling, and decrease joint destruction and disease progression.
Administration of CBD protect joints against severe damage, decreased progression and produces improvement of arthritis in animal models.
The first controlled trial showed that administration of Sativex over five weeks produced significant improvements in intensity of pain on movement and at rest, quality of sleep, and inflammation. No serious adverse effects were observed.
CBD increased tumor cell death in leukemia and colon cancer.
Cannabidiol May Promote Heart Health
Study reported that CBD caused dilation of arteries, and protected blood vessel from damage in animal models.
CBD reduced the infarct size (size of damage from clogged blood vessels) in the heart and brain, and irregular heart rhythms in animal models.
Studies showed that CBD reduced the heart rate and blood pressure in response to anxiety or stressful situations.
CBD also influenced white blood cell function and platelet aggregation.
However, further work is required to prove the ability of CBD to prevent the development of heart and blood vessels disorders in humans.
Resources and References
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